Kubatsira Neurological Disease
Zvisikwa ndechimwe chezvinonyanya kutsvakurudzwa uye zvakashandiswa zvakanyanya kuti zviwedzere kusimbisa musimba kukura uye simba. Inonyanya kufanirwa pakati pevatambi, vanovaka muviri uye avo vanoda kuvandudza mitambo. Zvisikwa zvinoratidzwa kuti ndeimwe yezvakanaka zveuchapupu-based approved supplements mumitambo yekudya . Kunyange zvazvo akaratidzirwa kuvandudza mishonga yekuvandudza, chisikwa chinonzi zvakare chinobatsira kune avo vanotambura nechirwere chepfungwa.
Kutsvakurudza kusingaperi kunoenderera mberi kutsigira creatine ichiita basa rinobatsira munharaunda yenheyo yenyika (CNS). Icho chinoratidzika kuti creatine supplementation inogona kuderedza zviratidzo zvezvirwere zveurourogenerative zvakadai saAlzheimer's, Parkinson's, ALS, uye Huntington's.
Chii chinonzi Creatine?
Zvisikwa chinhu chinowanzoitika chinobva kumamino acids glycine, arginine, uye methionine. Amino acids ndiwo mavharo eprotein. Zvisikwa zvinobudiswa muropa, itsvo, uye pancreas uye zvakanyanya kunyanya mumashuga emasumbu. Zvishoma zvishoma zvinoparadzirwa kuburikidza neropa redu kuuropi uye mamwe maviri.
Zvisikwa zvinowanikawo mumapuroteni emhuka semhuka sehove uye hove mune zvekuwedzera kubudiswa mumuviri.
Rinoshanda sei muMuviri Wedu
Zvisikwa zvine basa rekupa simba kumasero mukati memuviri nekuchengetedza masero emagetsi ekuenzanisa. Izvo zvinoitika zvakasikwa uye zvinowanikwawo kuburikidza nekudya zvimwe zvokudya zvekuwedzera.
Apo chisikwa chinopinda kana chichibudiswa nemuviri, chinopinda kuburikidza nekugadzirwa kwemakemikari uye mafomu creatine phosphate . Iyi molecule yakachengetwa inopa simba rekurumidza kumasero akave apera munguva yekunyanya muviri kana neuronal.
Creatine phosphate inonziwo phosphocreatine (PCr). Chimiro chinowedzera kurovedza muviri kuburikidza nekuwedzera PCR kana ATP (adenosine tri-phosphate). ATP ndiyo imwe simba rinoshandiswa munguva yekukurumidza kwemasimba semafuta kana kusimudza.
Iko yekuchengetedza kwekusika (phosphocreatine) ndiyo iyo nyanzvi yekushandisa simba inonzi inoburitsa zvishoma zvishoma zvekudzivirira muviri. Vatambi vanowedzera pamwe nemusiki nekuda kwekugona kwayo kupa simba uye kuwedzera ukuru hwemaviri.
Zvisikwa zvave zvichingova zvinopfuura mutambo wekusimudzira . Kutsvakurudza kwakaratidza kuti creatine inokosha zvikuru mukurapa chirwere chinonzi neurodegenerative. Kurapa kukwanisa kutarisa simba remagetsi simba rinogona kuderedza zviratidzo zvehutano hwepfungwa muvarwere.
Creine uye Neurological Research
Maererano nekutsvakurudza kwakabudiswa mu Journal of Nelomolecular Medicine, muumbi unoratidzwa kuva mushonga unoshanda weHuntington's naPalinson's disease. Zvinoratidzika kuti creatine inovandudza masero emagetsi emagetsi europi ekuderedza zviratidzo zvezvivhiringidzi zveurourogenerative.
Kutsvakurudza kwemazuva ekupedzisira ekugadzirisa kuwedzera kwakagadziriswa kuongororwa kwemigumisiro yakaitwawo. Vatanhatu vane makore makumi matanhatu vakaongororwa kwemakore maviri uye vakagamuchira 4g / d ye creatine kana placebo. Chinangwa chaicho chaive chikuru chekuita kuti basa rekudzivirira rive rakanaka kana richiwedzera pamwe nemusiki wezvirwere zvehutano. Zvisikwa zvakaratidzwa kuti zvinoregererwa muvatana vakwegura vane chirwere chePasinson. Iropi kana renal basa yakaramba iri mumiganhu yakasununguka uye chete iyo yakaipa yechirwere yakabuda yakaonekwa inowanzovhiringidzika mudumbu.
Zvimwe zvidzidzo zvinoratidza kuti creatine supplementation yekuvandudza mafungiro emagariro nekuyeuka vanhu vane hutano uye nekutanga kwechirwere cheAlzheimer's sick patients.
Zvinyorwa zvitsva zvakaitwa kune varwere vanorwara neLou Gehring Disease. Izvi zvinokonzerwa neurological disorder zvinokanganisa neurons ye-central nervous system. Zvisikwa zvakaratidzwa kuti zvive neuroprotective effect.
Kakawanda, creatine supplementation inoratidzirwa kugovera kudzivirirwa kwemaurological yemasero. Zvidzidzo zvenguva dzose zvinoratidza kuti creatine inoshanda neuroprotective agent. Varwere vanotora creatine vakave vakagadziriswa motokari basa uye huri nani hwehupenyu.
Tariro yezvirwere zvehutano
Panogona kuva netariro kune avo vanotambura nezvirwere zvepfungwa sezvakaita Parkinson's, Alzheimer's, Amyotrophic Lateral Sclerosis (ALS), uye Huntington.
Zvisikwa zvinoratidzika zviri kutamba basa rinokosha mukuchengetedza masero emagetsi. Kutsvakurudza kwakaratidza migumisiro inokurudzira mukuderedza kufambira mberi kweimwe zvirwere zvepfungwa.
Ikoko kunoratidzika kuva nechiratidzo chakasimba chekusika supplementation senzira yekurapa yekurapa zvirwere zvepfungwa. Izvo zvakanaka zvakawanikwa zvinotsigira mberi kutsvakurudza.
Chirwere chimwe nechimwe chinokonzerwa neurological chinopa nekusiyana kwekushaya simba kunogona kana kusingabatsiri kubva pakusika kuwedzera. Chirwere cheAlzheimer (AD) somuenzaniso chakawanikwa kuratidza kuvandudzwa pamwe ne creatine supplementation chete mumatanho ekutanga. Gare gare chirwere che AD chakanga chisina kubudirira nekuda kwezvisikwa zvisikwa zvakawanikwa muuropi.
Chirwere chePacinsinson (PD) chemakirini emakirini akaonesa zvingave ne creatine supplementation kunonoka kufambira mberi kwePD. Zvisikwa zvinoratidzika kuva nezvikomborero kwenguva refu kune vanhu vari kurwara nePP.
Amyotrophic Lateral Sclerosis (ALS) zvinosuruvarisa uye zvakafanana neAlzheimer's disease (AD) haina kupindura zvakajeka pakusika kuwedzera.
Creatine supplementation yakaratidza mikana yakawanda mukurapa chirwere cheHuntington (HD). Kutsvakurudza kunoratidza uchapupu hwakasimba mukuda kwekusika semunhu anoshanda neuroprotective agent kune chirwere ichi. Zvisikwa zvinogona kugadzirisa uye / kana kuwedzera hupenyu hwevanhu vanotambura neHD.
> Sources:
> Andreas Bender et al., Long-term creatine supplementation yakachengeteka kune vakwegura vane chirwere chePalinson, Research Nutrition , 2008
> Journal of Biomedicine uye Biotechnology, US National Library of Medicine, National Institutes of Health, The Creatine Kinase / Creatine Kubatana Nezvirwere zveAlzheimer: CK Inactivation, APP-CK Complexes, uye Focal Creatine Deposits, Tanja S. Bürklen et al., 2006
> Official Journal yeAmerican Academy of Neurology, neurology.org, PRECREST: Chikwata chechipiri chekudzivirira uye chemarker chekusika pachigunun'una chaHuntington chirwere, Herminia D. Rosas, MD uye al., 3/11/14
> Nyaya Yepamutemo yeAmerican Academy of Neurology, neurology.org, Chirwere chekushaya ruzivo, chine mapofu-mapofu, chekushaya ruzivo rwechirwere chekusika uye minocycline munguva yepakutanga kwePalinson disease, Dr. Bernard Ravina, 3/14/06
> US National Library of Medicine, National Institutes of Health, Subcellular Biochemistry, Inorativo yebumbiro rekusika, Klein AM, Ferrante RJ, 2007