Majini edu, nezvimwe zvikonzero, sarudza kuti caffeine inotikanganisa sei
Caffeine sensitivity inoreva kuwanda kweiyo caffeine kune miviri yedu. Vanhu vane ruzivo rwekushaya caffeine rusingaoneki vanogona kuona zviratidzo zvikuru - zvakadai sekuzvidya mwoyo, kudengenyeka, musoro, palpitations, uye kusuruvara - mushure mekudya kunyange zvishoma zvekudya zve caffeine-zvine zvokudya, Vanhu vane caffeine senitivity vanofanira kuedza kudzivisa caffeine zvachose.
Izvo zvinoita kuti munhu aine caffeine inotsanangurwa nezvimwe zvinhu zvinosanganisira makore uye zvepabonde, asi chikuru chinhu chinonzi genetic. Madzimai, hukama hwe caffeine hunosimbiswa zvikuru nekushandisa kwekudzivirira pamuviri, uye nekuzvitakura.
Maitiro eCaffeine anonzi Metabolized
Caffeine inokurumidza kubudiswa kubva mumatumbo kusvika muropa, uye inonyatsoyambuka dambudziko reropa-reropi muuropi. Izvowo inokwidza zvakasununguka muchengeti mumadzimai ane pamuviri.
Muchiropi, caffeine inosunga kune adenosine receptors, nokudaro kudzivirira adenosine kuti irege kuvabatanidza. Nokuti adenosine inotumira uropi shoko kuti inguva yekurara, kudzivirira adenosine receptors kune zvakakonzera kukura.
Caffeine inogadziriswa pachiropa neine enzyme inonzi CYP1A2 kune theophylline, paraxanthine uye theobromine, uye inobva yasunungurwa neitsvo mumuguta. Ihafu-yehupenyu ye caffeine inowanzova 4 - 6 maawa, izvo zvinowanzoita kuti caffeine yakareba kwenguva yakareba sei kwatiri.
Chii Chinokonzera Kenzaine Kuchengetedza?
Kunzwa kwe caffeine kunonyanya kusarudzwa nebasa reYYP1A2 enzyme muropa. Iyo inonyanya kushingaira CYP1A2, iyo isinganyatsozivi kuti tiri caffeine. Zvinhu zvakawanda zvinokonzera chirongwa cheYP1A2:
- Age: CYP1A2 basa rinowedzera kuderera nezera, saka vanhu vakwegura vanowanzova nehanya ne caffeine
- zvepabonde: vakadzi vanowanzova nechepasi CYP1A2 basa kupfuura varume.
- Kushandiswa kwemuviri kana kuti kubata pamuviri: estrogen inodzivisa chirongwa cheYP1A2, uye kushaya caffeine kunzwisisika kuwedzera
- Genetic makeup: Zviverengero zvakasiyana-siyana zvegene zvino zvakagadzirirwa zvinobata basa reYP1A2.
Zvitubu zvedu neCaffeine Kutsigira
Kuongorora maitiro ekuratidza zvirwere zvakaratidza zvitatu zvakasiyana-siyana zveukama hwe caffeine hune chokuita nemagetsi edu:
- Hypersensitive Caffeine : Vanhu ava vane basa rakaderera reYP1A2. Vachava nemhinduro yakasimba kune kunyange maduku madzimai ecaineine, uye vachawanzoona jitters nekushaya hope.
- Kazhinji Sensitivity kuKaffeine : Ichi ndicho chizhinji chevanhu. Vanokwanisa kudya kusvika 400 mg ye caffeine zuva rimwe chete pasina migumisiro yakaipa.
- Low Kuziva kuCaffeine : Vanhu ava vane yakakwirira zvikuru yeYYP1A2 basa, uye kazhinji havasati vava nemigumisiro zvachose kubva pakudya caffeine. Vakasvuta vanowanzowedzera basa re CYP1A2.
Nepo kuongorora mazita ekugadzira kunogona kuisa chikwata chako che caffeine senitivity, kuedza kuongororwa kwakanyanya hakudi kuti iwe uzive - kunyanya kakawanda kutaura-kana iwe iwe unonyanya kufarira caffeine. Uye kana iwe uri, zvichida hapana munhu anoda kukuudza kuti udzike shure.
Kubata uye Caffeine Sensitivity
Kuberekwa kunovhiringidza kunowedzera kushushikana ne caffeine. Iyo hafu-hupenyu hwea caffeine muvakadzi vane pamuviri kanowanzove yakapetwa katatu kupfuura yevakadzi vasina pamuviri - kazhinji kusvika maawa makumi matanhatu. Uyezve, caffeine inopinda muropa remu fetus - uye fetus ine, zvikuru kwazvo CYP1A2 basa. Kunyange zvazvo zviitiko zvakakomba zvakakomba pamucheche wakakonzerwa newaamai yea caffeine hazvina kunyorwa, nyaya iyi haina kudzidza zvakanyanya. Mukati, vakadzi vane pamuviri vanofanira kuedza kudzivirira kana kudzivisa caffeine.
> Sources:
> Cornelis MC, Byrne EM, Esko T, et al. The Coffee uye Caffeine Genetics Consortium. Meta-analytical-wide meta-analysis inoratidzira nhamba nhanhatu inoichi inosangana nechinangwa chekudya. Molecular Psychiatry 20, 647-656 (May 2015) | doi: 10.1038 / mp.2014.107
> Grant DM, Tang BK, Kalow W. Kusiyana mu caffeine metabolism. Clinical Pharmacology & Therapeutics, 33 (5), 591-602, 1983.
> Grosso LM, Bracken MB. Caffeine metabolism, genetics, nemigumisiro yepininatal: kubvunzurudzwa kwekutsvaga kuongororwa kwepfungwa panguva yekuzvitakura. Ann Epidemiol 2005; 15: 460.