Androstenedione (Andro) ishandisi yekuwedzera musimba iyo baseball kumba inomirira nyanzvi Mark McGwire yakaitwa mukurumbira. Asi kubva panguva iyoyo, yakave yakarongerwa steroid ya anabolic uye zvakadaro, hazvisi pamutemo kushandiswa pasina chikonzero chekurapa chairo.
Inonziwo: 4-androstenedione kana 4-androstene-3, 17-dione
Chinonzi Androstenedione Chipi?
Androstenedione yakagadzirwa kubva pane zvakasikwa steroid hormone.
Mumuviri wako, androstenedione inonzi prohormone inokonzerwa ne-adrenal glands, testes, uye mavari. Muviri unoshandura uyerostenedione mu testosterone , iyo huru yemhomoni, uyewo mu estrogen estrone uye estradiol. Apo pakashandisa andro sekuwedzera kune mutemo, yakashandiswa mune tariro yekuwedzera maitiro e testosterone mumuviri. Mukuwedzera kupa varume nemadzimai maitiro evanhu, testosterone ine vanabolic effect, kuwedzera ukuru hwemasumbu uye simba.
Therapeutic androstenedione inogona kushandiswa kuwedzera maepermasterone eplasma. Zvidzidzo kazhinji hazvina kuwana androstenedione kuwedzera kuti ibudirire pakuwedzera maitiro e testosterone. Zvimwe zvidzidzo zvakaratidza kuti mambure ekugadzirwa kwaiva kukusimudzira chiyero cheestrogen pane, uye akanga asina vanabolic effect pamasumbu mune varume vechidiki. Inoshandiswa sekuwedzera, iyo inoonekwawo kuva nemigumisiro yakaipisisa mukuderedza HDL cholesterol, iyo inogona kukonzera chirwere chemwoyo chinokanganisa mumarume.
Androstenedione Shandisa Mumutambo
Kwemakore Major League Baseball haina kurambidza uyero pasinei nehuchapupu hwokuti kushandiswa kwayo kunogona kuva nengozi kune avo vanoitora pasina chikonzero chekurapa chairo. Yakanga yapfuura yakarambidzwa neAnti-Doping Agency, International Olympic Committee, NCAA, NFL uye kutenderera kwevarume nevakadzi.
MunaJanuary muna 2005, the Anabolic Steroid Control Act yakagadziriswa neMutemo weChirongwa Chechipiri chakawedzera vanabolic steroid uye prohormones kune urongwa hwezvinhu zvinodzorwa. Izvi zvinokonzera kuti zvinhu zvive zvematongerwe enyika. Muna 2004, United States Chakudya neDrug Administration (FDA) rakarambidza kutengeswa kweAndro, nekuda kwehumwe uchapupu hunotsigira huwandu hwehutano hwakanyanya pakushandisa ichi chinhu.
FDA Inonzi Alert Alert 54-11, yemu 9/15/2015, inopa kutungamirirwa kumatunhu ndeyokuti chero kudya kwezvokudya zvinowedzera androstenedione, 4-androstenedione kana 4-androstene-3, 17-dione inogona kusungwa isina kuongorora. Kungongorongedza izvi ndiko kunokonzera kudzivirira kwaro kupinda muUnited States.
Migumisiro Yechiri
Tsvakurudzo yainge yakasanganiswa kana kuti andro yakawedzera yakashanda zvachose kusimudza maitiro e testosterone, asi yakaratidzwa kuva nemigumisiro yakaipa uye kuwedzera ngozi dzehutano.
Inogona kuwirirana neropa rakaonda seCoumadin uye salicylates. Inogonawo kubatana nechirwere cheshuga chinosanganisira sulfonylurea uye insulin, inoderedza ropa glucose. Iyo inogona kutungamirira kune zvakanyanya acne kana edema kana yakatorwa ne corticosteroids.
IUF FDA White Paper pamusoro pehutano hweAndrostenedione muna 2005 yakataura nezvekukanganisa kwavaiita kuti vaizoitika kune vana nevechiri kuyaruka vakatora uyero kwenguva refu.
Izvi zvaisanganisira kubatana kwevakomana uye virilization kuvasikana. Kutanga kusangana nehupombwe kunogona kutungamirira kufupi shoma.
Kuwedzera testosterone mumarume akwegura kunogona kukonzera njodzi yakawanda yekukura kwekenza yeprotate, uyewo kukura kwekenza yeropa nechifuva chemuti mune varume nevakadzi.
Sources:
National Center ye Biotechnology Information. PubChem Compound Database; CID = 6128, https://pubchem.ncbi.nlm.nih.gov/compound/6128
US FDA; FDA White Paper Migumisiro Yemutano weAndrostenedione. March 11, 2004
Thomson.Micromedex. Information Drug for Health Care Professional. 25th ed. Bhuku 1. Plus Updates. Zviripo Zvakaongororwa neUnited States Pharmacopeial Convention, Inc. Greenwood Village, CO 2005., p. 142.