Pane humwe humwe huchapupu hwakakwana hunotsigira kushandisa iyi yekuwedzera kwekurasikirwa nekurema here?
Chinhu chechisikigo chinogona kuderedza nhumba dze nzara, 5-HTP (5-Hydroxytryptophan) inobatanidzwa neL-tryptophan, rudzi rweprotini inowanikwa mune zvimwe zvokudya zvekudya. Kana ikashandiswa sekureruka kwekubatsira, 5-HTP inowanzosvibiswa kubva kumbeu yeGriffonia simplicifolia plant.
5-HTP inozivikanwa kuti iwedzere kubudiswa kwe serotonin muuropi uye pakati penheyo system.
Mhando yeurourotransmitter (kemikemikari inotakura kutakura mashoko pakati pemasero emagetsi), serotonin inobatsira kudzora kudya . Nokudaro, vamwe vanotsigira mishonga vanodaro vanoti kushandiswa kwe5-HTP kunogona kubatsira kusimudzira kuora kwemazuva nekuchengeta chido chako chekutarisa uye, zvakare, kuderedza kudya kwako kudya.
Zvinotsvakurudzwa Nezvekutsvaga Nezve Makomborero e 5-Hydroxytryptophan
Maererano neNational Institutes of Health (NIH), hapana huchapupu hwakakwana hwezvesayenzi hunofanirwa kuverenga kubudirira kwekutora 5-HTP kunowedzera kushaya kurasikirwa kana kuneta. Zvisinei, iyo NIH inotsanangura kuti imwe tsvakurudzo yekutanga inoratidza kuti 5-HTP inogona kubatsira kubvisa chido, kuderedza caloric kudya, uye kuderedza uremu kuvanhu vakawanda.
Inotsvakurudza iripo inosanganisira kudzidza kwekare kubva muna 1992 yakabudiswa muAmerican Journal of Clinical Nutrition . Padzidzo, makumi maviri nevatori vechikamu vakashandiswa kuti vawane 5-HTP kana kuti placebo kwemavhiki matanhatu matanhatu.
Kunyange zvazvo pasina kudya kwairehwa munguva yekutanga yekudzidza, kuderedza-koriori kudya kwakakurudzirwa kwechipiri. Zvidzidzo zvekudzidza zvakaratidza kuti nhengo dzeboka re-5-HTP dzakaona kurasikirwa kwemahombekombe panguva dzose mbiri. Mukuwedzera, nhengo dzeboka re5-HTP dzaive nekuderedza kudya kwekakidhyidhe uye chido chekuwana satiety (kunzwa kwakazara) pakutanga panguva yaidya.
Mune imwe dzidzo (yakabudiswa mu International Journal of Obesity uye Related Related Metabolism Disorders muna 1998), vatsvakurudzi vakawana kuti 5-HTP yakaderera zvikuru kudyiwa kwezuva nezuva kwekoriyori uye kuderedza uremu hwehuwandu hwevanhu vakuru vanoremekedzwa vane chirwere cheshuga chechipiri. Chidzidzo chacho chaisanganisira vanhu vane makore makumi maviri uye makumi maviri vakawandisa vane chirwere cheshuga chechipiri, vane mapfumbamwe avo vakapiwa 5-HTP uye 11 vakagadzirirwa nzvimbobo.
Pane kushayikwa kwekutsvakurudza kwezvino pfupi kubudirira kwe 5-HTP mukusimudzira kurasikirwa kwemaima.
Zvinokwanisika Serious Side Effects ye 5-HTP
Maererano neNIH, kushandiswa kwe-5-HTP kuwedzera kunogona kusanganiswa ne eosinophilia-myalgia syndrome (EMS), chirwere chakakomba chinokonzera kushungurudzika kwepfungwa uye ropa risina kunaka.
Muna 1989 na1990, pakanga pane chirwere cheEEMS pakati pevanhu vakange vashandura L-tryptophan (anonyanya kusvika 5-HTP). Pakaongororwa, chirwere chacho chakanga chichidzokera kune rimwe chete uye chakanzi kunosvibiswa kunokonzerwa nokucheneswa kusina kukodzera pamwe chete nechangobva kubudiswa kushandiswa. Kunyange zvazvo kugadzirwa kwemabhizimisi e5-HTP kusingashandisi nzira dzakadaro dzekuvirisa, iyo NIH inokurudzira kudzivisa kushandiswa kwe-5-HTP kunowedzera kusvikira mamwe anozivikanwa nezvekuchengetedzwa kwavo.
Zvakakosha kuchengetedza mupfungwa kuti zvidimbu hazvina kuongororwa kuchengetedzwa uye zvokudya zvekudya zvinowanzosaregererwa.
Mune zvimwe zviitiko, chigadzirwa chacho chinogona kutakura dhesi dzinopesana nemari yakatarwa yemiriwo imwe neimwe. Mune dzimwe nguva, chigadzirwa chacho chingave chakasvibiswa nezvimwe zvinhu zvakadai sesimbi. Uyewo, kuchengeteka kwezvokuwedzera mumadzimai ane pamuviri, vanaamai vanoyamwisa, vana, uye avo vane zvirwere kana avo vari kutora mishonga haisati yasimbiswa.
5-HTP inozivikanwa kuti inotanga mimwe miviri yemigumisiro, kusanganisira:
- Kushungurudza
- Dumbu remarwadzo
- Nausea
- Kudzora
- Diarrhea
- Kukurova
- Zvinetso zvepabonde
- Zvinetso zvematumbo
Anozivikanwa 5-HTP Kurapa Kwezvinodhaka
Mukuwedzera, kutora 5-HTP pamwe chete nemimwe mishonga inogona kuunza zvinokuvadza.
Iyi mishonga inosanganisira antidipressant drugs (yakadai seProzac® uye Zoloft®), dextromethorphan (Robitussin DM®, nevamwe), uye meperidine (Demerol®). 5-HTP inogonawo kusangana nemhando dzakawandisa yemishonga, kusanganisira St. John's wort uye S-adenosylmethionine.
Iwe unogona kuwana mamwe mazano ekushandisa mashandisiro pano.
Kushandisa 5-HTP yekurema kwekutakura
Pamusana pezvinetso zvekuchengeteka, NIH inopa zano pamusoro pekutora 5-HTP mune fomu yekuwedzera. Mukuwedzera, pane humwe humwe uchapupu hunotsigira kudai kuti 5-HTP inowedzera inogona kutsigira kurasikirwa kweropa.
Kana uri kufunga nezvekushandiswa kwe-5-HTP kunowedzera kushaya kurasikirwa (kana kune chero humwe humwe hutano hwakabatana), zvakakosha kutaurirana nemutarisiri wako usati watanga regimen yako yekuwedzera. Kuzvibata uye kudzivisa kana kunonoka kutarisirwa kwese kunogona kuva nemigumisiro yakakomba.
Sources:
Bell SJ, Goodrick GK. "Chigadzirwa chekudya chakakosha chekutarisira uremu." Crit Rev Food Sci Nutriti. 2002 Mar; 42 (2): 163-78.
Cangiano C, Ceci F, Cascino A, Del Ben M, Laviano A, Muscaritoli M, Antonucci F, Rossi-Fanelli F. "Kudya tsika nekuteerera mitemo yezvokudya mumatunhu akare akaremberedzwa ane 5-hydroxytryptophan." Am J Clin Nutriti. 1992 Nov; 56 (5): 863-7.
Cangiano C, Laviano A, Del Ben M, Preziosa I, Angelico F, Cascino A, Rossi-Fanelli F. "Migumisiro yemuromo 5-hydroxy-tryptophan pamusana wekugadzira simba uye macronutrient musarudzo isina muropa yevanhu vane chirwere cheshuga." Int J Obes Relat Metab Dambudziko. 1998 Jul; 22 (7): 648-54.
Hendricks EJ, Rothman RB, Greenway FL. "Nyanzvi dzinobata unyanyisa chiremba dzinoshandisa zvinodhaka kuti zvirape kuneta." Kuwedzera muviri (Silver Spring). 2009 Sep; 17 (9): 1730-5.
National Institutes of Health. "5-HTP: MedlinePlus Zvinyorwa." May 2011.
Zvinonzwisisika: Mashoko anowanikwa pane ino yepaiti inoitirwa zvinangwa zvekudzidzisa chete uye haisi kutsiva mazano, kuongororwa kana kurapwa nechiremba ane chiremba. Hazvirevi kuvhara zvose zvinogona kumira, kushamwaridzana kwezvinodhaka, mamiriro ezvinhu kana zvinetso zvakashata. Iwe unofanirwa kutsvaga kurapwa nokukurumidza mune zvehutano kune chero hutano hwehutano uye bvunza chiremba wako usati washandisa mamwe mushonga kana kuita shanduko kune regimen yako.